2015 Fiscal Year Final Research Report
Evaluation of correlation between rotation and secretion of type III secretion apparatus for clarifying the effector secretion mechanism
| Project/Area Number |
26891024
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Keywords | 細菌Ⅲ型分泌装置 / 緑膿菌 / 回転-分泌相関 |
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| Outline of Final Research Achievements |
Bacteria like Pseudomonas aeruginosa inject effector proteins, which contribute to bacterial infection, into host cytosol via needle-like type III secretion machinery (T3SA). However, the transport mechanism of effectors in T3SA is unclear. In this study, we measured the speed of effector transport in T3SA. The measured speed of effector transport in T3SA showed correlation with the speed of T3SA rotation previously observed. Consequently, it was suggested that effecters are transported in T3SA needle by the rotation of T3SA.
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| Free Research Field |
生物物理学
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