The study for the mechanism, treatment and prophylaxis of the pain that has derived from osteoporosis and sarcopenia.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26893034
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Epidemiology and preventive medicine
• Research Institution: Chiba University
• Principal Investigator: Suzuki Miyako 千葉大学, 予防医学センター, 助教 (70734242)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: 骨粗鬆症由来疼痛 / 慢性疼痛 / サルコペニア / 卵巣摘出マウスモデル

Outline of Final Research Achievements

There were significant intergroup differences in the behavioral measures at baseline, and the pain sensitivity in the Ovariectomized mice significantly increased. Six months postoperatively, animals were treated with morphine and pregabalin, and they were treated for 5 wk with a bisphosphonate, pamidronate. Pregabalin was highly effective against mechanical, cold, and heat hypersensitivity in the OVX group, but morphine was only associated with mild efficacy against mechanical and cold stimuli. Chronic bisphosphonate treatment improved both vertebral BMD and hypersensitivity to cold with significant correlations in the OVX group.
This OVX-induced mouse model of osteoporosis showed pain-related behavior, including radiating and axial pain. Osteoporosis-related pain was significantly attenuated by bisphosphonate and pregabalin. Therefore, the expression of osteoporosis-related pain is involved in osteoporotic vertebrae, and osteoporosis-related pain has a neuropathic component.

Free Research Field

整形外科学、予防医学