2015 Fiscal Year Final Research Report
The functional role of Eph/ephrin signal as neuron-glia communication in the regulation of brain Abeta level
| Project/Area Number |
26893042
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Hori Yukiko 東京大学, 薬学研究科(研究院), 助教 (80610683)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Keywords | 脳神経疾患 / 神経科学 / アルツハイマー病 |
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| Outline of Final Research Achievements |
Amyloid-β peptide (Aβ) is linked to the pathogenesis of Alzheimer disease (AD). Therefore, it is important to reveal the mechanistic insights underlying regulation of brain Aβ level. In this research, we examined the functional role of EphA4/ephrin signal as neuron-glia communication in the regulation of brain Aβ level. We found that EphA4/ephrin signal modulates the Aβ level by altering the protein level of BACE, which is a limiting enzyme for Aβ production.
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| Free Research Field |
医歯薬学
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