2015 Fiscal Year Final Research Report
Elucidation and Application of Tissue-specific Regulatory System in Mast Cells
| Project/Area Number |
26893047
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Keywords | マスト細胞 / 皮膚科学 / 接触性皮膚炎 / 線維芽細胞 / 受容体 |
|---|
| Outline of Final Research Achievements |
Mast cells are known as effector cells in various allergic diseases and have been classified into connective tissue type (e.g. skin, blood vessel, and peritoneal cavity) and mucosal tissue type (e.g. lung and intestinal mucosa).
In this research, we have found tissue specific gene expression patterns in mast cells and a surface molecule bearing inhibitory motif was strongly expressed in the skin mast cells but not in mast cells located in the other tissues.
Mice lacking this molecule were sensitive to skin inflammations compared to wild type mice. These findings suggested that regulation of this molecule would be novel strategies for the suppression of skin inflammation.
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| Free Research Field |
免疫学、粘膜免疫学
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