The study about the effect of stretch on the differentiation of cardiac fibroblast

2015 Fiscal Year Final Research Report

• Project/Area Number: 26893049
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Cardiovascular medicine
• Research Institution: Dokkyo Medical University (2015); The University of Tokyo (2014)
• Principal Investigator: OBI SYOTARO 獨協医科大学, 医学部, 講師 (10734452)
• Research Collaborator: HASEGAWA TAKAAKI 獨協医科大学, 心臓血管内科, 研究員
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: 機械的刺激

Outline of Final Research Achievements

Human　cardiac　fibroblast　cells　were　exposed　to　cyclic　stretch.　Cyclic　stretch　induced　the　morphological change. Cyclic stretch increased the protein and mRNA expression level of aSMA. On the other hand, it decresed the protein expression level of collagen type1, fobronectin, BNP, and NEP. Human cardiac fibroblast expresses TRPV1, 2, 3, and 4. TRPV2 agonist and TRPV4 agonist increased the intracellular calcium flow, while TRPV1 agonist did no change it.

Free Research Field

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