2015 Fiscal Year Final Research Report
Analysis of B cell involvement in progression and immune evasion in cutaneous lymphoma
| Project/Area Number |
26893052
|
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| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
|
|---|
| Research Institution | The University of Tokyo |
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Principal Investigator |
|
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| Project Period (FY) |
2014-08-29 – 2016-03-31
|
| Keywords | 皮膚悪性リンパ腫 / B細胞 / サイトカイン |
|---|
| Outline of Final Research Achievements |
The ratios of IL-10-producing regulatory B cells, CD24(hi)CD27(+) B cells, and CD24(hi)CD38(hi) B cells were significantly decreased in peripheral blood of patients with CTCL. The numbers of them were significantly inversely correlated with serum LDH levels, one of the disease severity markers of CTCL. Thus, regulatory B cells might be associated with progression of CTCL.
The expression levels of VEGF-A in lesional skin and sera in patients with CTCL were significantly elevated. VEGF-A expression levels were correlated with CCL27 expression levels in lesional skin, one of the disease severity markers, and clinical and serological markers for pruritus. Thus, VEGF-A can be associated with disease progression and pruritus in CTCL.
|
| Free Research Field |
医歯薬学
|
