The pathological role of brown adipose tissue dysfunction in age related disorders.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26893080
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: Niigata University
• Principal Investigator: Shimizu Ippei 新潟大学, 医歯(薬)学総合研究科, 特任准教授 (60444056)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: 褐色脂肪 / 心不全 / 肥満 / NASH / 褐色アディポカイン

Outline of Final Research Achievements

Accumulating evidence indicates that brown adipose tissue (BAT) is the critical regulator for systemic metabolic dysfunction. Our results suggested that BAT dysfunction develops upon left ventricular pressure overload in a murine heart failure model, and causal for the progression of heart failure. BAT transplantation ameliorated cardiac dysfunction. We are currently examining to find a novel metabolites involved in disturbing cardiac metabolism with metabolome analyses. We also found that in dietary obese model, obesity associated pro-fibrotic protein (OAFP) is produced and secreted predominantly from BAT and promotes fibrosis in the liver. OAFP level in the serum was also increased in non alcoholic steatohepatitis (NASH) patients, and OAFP gain of function model promoted fibrosis in the liver. Further studies would elucidate the pathological role of OAFP in NASH.

Free Research Field

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