2015 Fiscal Year Final Research Report
The search for new anti-cancer drug therapy in biliary tract cancer (targeted to Aquaporin)
| Project/Area Number |
26893091
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | University of Toyama |
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Principal Investigator |
Sekine Shinichi 富山大学, 大学院医学薬学研究部(医学), 助教 (60649292)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Keywords | 胆道癌 / アクアポリン / 化学療法 |
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| Outline of Final Research Achievements |
We examined AQP expression by tissue microarray (TMA).In biliary tract cancer cell lines after the bile acid exposure showed a decreased expression of AQP-1 gene.AQP-1 was involved in the progress of cholestasis and cancer. AQP-1 were considered to be useful as a prognostic factor in biliary tract cancer.In biliary tract cancer patients who underwent chemotherapy, PTEN expression group, compared to a non-expression group had a good prognosis (DSS; p <0.01).Our result suggest that AQP and PTEN may contribute to the apoptosis and chemotherapy sensitivity.
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| Free Research Field |
医歯薬学
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