2015 Fiscal Year Final Research Report
Mechanism elucidation and therapeutic development of sleep disorder induced by chronic pain
| Project/Area Number |
26893092
|
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| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Anesthesiology
|
|---|
| Research Institution | University of Toyama |
|---|
Principal Investigator |
|
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| Project Period (FY) |
2014-08-29 – 2016-03-31
|
| Keywords | 慢性痛 / 睡眠 |
|---|
| Outline of Final Research Achievements |
We analyzed the electroencephalogram of neuropathic pain model mice and evaluated the effects of amitriptyline (Tricyclic antidepressants) and MDL 100907 (selective 5-HT2A receptor antagonist) on sleep their conditions. As a results, we found that amitriptyline and MDL 100907 improved the sleep disturbance induced by chronic pain.Our results suggest that amitriptyline improves secondary sleep disturbance to regulate the overactive of 5-HTergic neurons induced by chronic neuropathic pain.
|
| Free Research Field |
麻酔科学
|
