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2015 Fiscal Year Final Research Report

Epigenetic regulation of the luteinizing hormone receptor

Research Project

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Project/Area Number 26893112
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionNagoya University

Principal Investigator

Nakamura Tomoko  名古屋大学, 医学部附属病院, 助教 (40732681)

Project Period (FY) 2014-08-29 – 2016-03-31
Keywordsエピジェネティック制御
Outline of Final Research Achievements

The normal growth of the granulosa cells is essential for obtaining a high-quality egg with a high potential to be fertilized. Granulosa cells, which support the growth of eggs, begins and increases its expression of the luteinizing hormone receptor (LHR) as the ovarian follicle grows. Here we studied the epigenetic regulation of LHR expression. Epigenetics is the regulation of gene expression which do not involve changes in the underlying DNA sequence. Such regulations include histone modification and DNA methylation. In this study, we studied histone modifications and DNA methylations of the LHR promoter region. Our results show that histone acetylation of H4K8 and H3K9, and DNA metylation of the 2nd,4th 5th and 9th CpG sites are important in elevating LHR expression.

Free Research Field

不妊生殖

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Published: 2017-05-10  

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