2015 Fiscal Year Final Research Report
Investigation of the regulatory mechanism of perinatal cardiomyocyte maturation
| Project/Area Number |
26893124
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Keywords | 心筋分化 / 心発生 |
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| Outline of Final Research Achievements |
Proliferative capacity of adult mammalian cardiomyocytes is very limited. However, its regulatory mechanism is still unclear. Since the recent studies have suggested that the cardiomyocytes soon after birth retain the proliferative capacity to repair damaged cardiac tissue in vivo, we searched possible regulatory factors of cardiomyocyte proliferation among the genes expressed dominantly in perinatal mouse heart and identified several genes that are expressed dominantly in the perinatal stage and also promote proliferation in H9C2 cells by using immunohistochemistry of mouse heart tissue, gene knockdown and overexpression in vitro. Next we investigate the molecular mechanism by which these genes regulate proliferation of the cells including cardiomyocytes.
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| Free Research Field |
循環器内科学
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