2015 Fiscal Year Final Research Report
Functional analysis of new cancer-restraining gene AES of the prostate cancer
| Project/Area Number |
26893130
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Kyoto University |
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Principal Investigator |
Okada Yoshiyuki 京都大学, 医学(系)研究科(研究院), 助教 (60739291)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Keywords | AES / 前立腺癌 |
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| Outline of Final Research Achievements |
Expression levels of AES were inversely correlated with clinical stages of human PCa. Exogenous expression of AES suppressed the growth of LNCaP cells, whereas the AES knockdown promoted it. We also found that AES suppressed transcriptional activities of AR and Notch signaling. Notably, AES overexpression in AR-defective DU145 and PC3 cells reduced invasion and metastasis to lymph nodes and bones without affecting proliferation in culture.
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| Free Research Field |
前立腺癌
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