2015 Fiscal Year Final Research Report
Analysis of the regulatory mechanism of FGF-2 by periodontal ligament specific molecule, PLAP-1
| Project/Area Number |
26893146
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Keywords | 歯周再生医学 / 歯周病 / 歯周組織再生療法 / 歯根膜 / PLAP-1 / FGF-2 |
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| Outline of Final Research Achievements |
PLAP-1 is an extracellular matrix protein that is predominantly expressed in the periodontal ligament within periodontal tissue. It was previously revealed that PLAP-1 negatively regulates BMP-2 and TGF-β activity through direct interactions. However, the interaction between PLAP-1 and FGF-2, which is a critical growth factor in tissue homeostasis and repair, has not been defined yet. In this analysis,we revealed that PLAP-1 positively regulates FGF-2 activity. Topical application of recombinant FGF-2 in intrabony defects significantly stimulates periodontal regeneration. This approach may be useful in several regenerative medicine applications using extracellular matrixs and growth factors concomitantly.
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| Free Research Field |
歯周病学
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