Establishment of autoantigen-specific immune suppressive therapy induced by self-tolerance

2015 Fiscal Year Final Research Report

• Project/Area Number: 26893150
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Collagenous pathology/Allergology
• Research Institution: Kobe University
• Principal Investigator: Kasagi Shimpei 神戸大学, 医学部附属病院, 助教 (80457051)
• Research Collaborator: Chen Wanjun National Institute of Health, MD
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: 免疫寛容

Outline of Final Research Achievements

Here we utilized Type 1 diabtes model mice and established autoantigen-specific immune suppressive therapy meditaed by self-tolerance. Combination thearpy of anti-CD20 antibody(B cell depletion therapy) followed by administration of self-peptide (GAD65)in NOD mice achieved long-term disease remission.We revealed that disease remission was achieved by selective induction of GAD65-specific regulatory T cells and, also,TGFb was indispensable in this therapy. However, the mechanism still remains unclear and addtional experiments are required to examine the role of macrophages and other immunoregulatory cells than regulatory T cells.

Free Research Field

免疫学