2015 Fiscal Year Final Research Report
metabolic analysis of therapy resistant cancer stem cell
| Project/Area Number |
26893172
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Yamaguchi University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-08-29 – 2016-03-31
|
| Keywords | 間葉系幹細胞 / 癌幹細胞 / マーカー / ALDH |
|---|
| Outline of Final Research Achievements |
To characterize cancer stem cell and normal tissue stem cell, we investigated marker expression in normal mouse adipose-derived stem cell. As a screening result of analysis for surface markers, phosphorylation-specific antibodies, and aldehyde dehydrogenase activity (ALDH), small subpopulation with high ALDH activity (ALDHhi cells) was found. ALDHhi cells showed higher ability to differentiate to ostogenic lineage. Further analysis on gene expression using microarray and gene expression enrichment analysis is in progress.
|
| Free Research Field |
幹細胞生物学
|
