The effect and role of SOCS (suppressor of cytokine signaling) in the cancer vaccine therapy for biliary tract cancer.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26893183
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Kyushu University
• Principal Investigator: OGATA HISANOBU 九州大学, 生体防御医学研究所, 助教 (70432945)
• Research Collaborator: TANI Kenzaburo 東京大学, 医科学研究所, 特任教授 (00183864)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: 癌ワクチン / 胆道癌 / 免疫

Outline of Final Research Achievements

The applicants have performed the cocktail peptide cancer vaccine therapy Phase II clinical trial for the patients with the advanced biliary tract cancer that are resistant to current therapy. One of the cocktail peptide, OCV-105 to use for this clinical study was identified as a gene frequently expressed in pancreatic cancer and cholangiocarcinoma tissues by the comprehensive genome information by the cDNA microarray, and is the HLA-A2402-restricted epitope peptide which can induce CTL. Other two, elpamotide and OCV-101 to use in this trial are HLA-A-restricted epitope peptides derived from VEGFR1, 2 and are a receptor of VEGF-A. The induction of CTL targeting this receptor might be expected to inhibit the growth and metastasis of cancer cell.

Free Research Field

消化器病学、肝臓病学、腫瘍学、免疫学、分子生物学

Academic Significance and Societal Importance of the Research Achievements

癌ワクチン療法における免疫学的解析をおこなう予定である。癌ワクチン療法における免疫学的解析をおこなった研究は少なく、学術的意義や社会的意義の高いものになると思われる。