Control of bone destruction by RBP4, an inducible factor of diabetes

2015 Fiscal Year Final Research Report

• Project/Area Number: 26893194
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Morphological basic dentistry
• Research Institution: Kyushu University
• Principal Investigator: KYUMOTO YUKARI 九州大学, 歯学研究科(研究院), 助教 (40729026)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: 破骨細胞 / 骨吸収 / RBP4

Outline of Final Research Achievements

Recently, it is reported that obesity or obesity-related development of diabetes are deeply involved in the increase of fracture risk, acceleration of bone resorption, and development of periodontal disease. Abnormal production of an adipokine, which is physiologically active substance secreted from adipose tissue, is a factor of these risk, however, the association of adipokines and osteoclasts specialized in bone resorption are poorly understood. We showed the possibility that RBP4, an adipokine which is a factor to induce diabetes, negatively regulates the osteoclast differentiation. Therefore, RBP4 could be a new target for the control of bone destruction.

Free Research Field

分子薬理学