The relation between Warburg effect and chemotherapy resistance in esophageal cancer.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26893203
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Kumamoto University
• Principal Investigator: SAWAYAMA Hiroshi 熊本大学, 医学部附属病院, 非常勤診療医師 (40594875)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: Warburg effect / 食道扁平上皮癌 / FDG-PET / Glut1 / glucose transporter / chemotherapy resistance

Outline of Final Research Achievements

Cancer cells exhibit altered glucose metabolism, termed the Warburg effect, which is described by the increased uptake of glucose and the conversion of glucose to lactate in cancer cells under adequate oxygen tension. Overexpression of transcriptional factors, metabolite transporters and glycolytic enzymes was associated with poor prognosis and may be associated with chemoradiotherapy resistance in multiple gastrointestinal cancer cell types. In esophageal squamous cell carcinoma, the expression of glucose transporter 1 (Glut1) increased. Glut1 positivity of biopsy before chemotherapy was associated with the reduction rate of FDG-PET SUV max after chemotherapy. Glut1 may be significant biomarkers for predicting the resistance of chemotherapy.

Free Research Field

癌と代謝