2015 Fiscal Year Final Research Report
Histopathological analysis of coronary materials of patients with acute coronary syndrome to prevent the recurrence
| Project/Area Number |
26893210
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cardiovascular medicine
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Keywords | 急性冠症候群 / 免疫組織化学 |
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| Outline of Final Research Achievements |
Calcification is frequent in human coronary arteries. We investigated the prevalence of calcification of materials aspirated during percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI), and assessed whether calcification is related to the clinical characteristics. In this study, coronary materials were obtained during PCI from 274 AMI patients. The presence of calcification in aspirated materials was morphologically assessed. Calcification was found in 44 (16%) of 274 patients, and it was not related to in-hospital death. Multivariate analysis identified multivessel coronary artery disease and female as independent predictors of the calcified deposition in culprit lesions. Additionally, final Thrombolysis in Myocardial Infarction flow grade tended to be lower in patients with calcification. These findings might provide an insight into the pathophysiology of AMI.
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| Free Research Field |
循環器病学
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