Involvement of TRPA1 in oral cancer-induced mechanical pain

2015 Fiscal Year Final Research Report

• Project/Area Number: 26893243
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Functional basic dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: Ono Kentaro 九州歯科大学, 歯学部, 准教授 (40316154)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: TRPA1 / P2X3 / ATP / ガン性疼痛 / 接触痛

Outline of Final Research Achievements

Oral cancer induces pain during meals when food and teeth touch on cancer region. In previous studies, it has been reported that adenosine triphosphate released from cancer causes mechanical pain. However, it is unclear which mechano-sensitive channels are involved. In this study, we investigated whether the mechano-sensitive channel TRPA1 is related in cancer-induced mechanical pain. Consequently, we revealed that mechanical pain is mediated by sensitization of TRPA1 following activation of P2X3 in the response to adenosine triphosphate.

Free Research Field

神経生理学