2015 Fiscal Year Final Research Report
Development of bone substitute material using artificial collagen/nano-size apatite complexes
| Project/Area Number |
26893247
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Keywords | 生体材料 / ナノアパタイト / 合成コラーゲン / コラーゲン複合体 / 硬組織再生 / 医療デバイス |
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| Outline of Final Research Achievements |
(1) We produced artificial collagen/nano-size apatite complexes, and evaluated histological reactions in mouse back soft tissues and bony tissue reactions at rat cranial bone defects to produce biological safe osteo-conductive bio-materials. In soft tissues, phagocytes entered deep inside complexes due to hydrophilicity. At bony defects, middle degree osteo-conductions was observed.
(2) We cultured osteoblastic SaOS-2 cells, extracted genes (mRNAs) and evaluated gene expression by RT-PCR, using primers of osteoblastic differentiations. On collagen/nano-size patite, one gene (Alkaline phosphatase) expressions was more accelerated than on collagen only control, suggesting that nano-size apatite was useful to form new bone.
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| Free Research Field |
歯科インプラント学
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