The expression and function of Heme Oxygenase in epidermal development and stress regulation

2015 Fiscal Year Final Research Report

• Project/Area Number: 26893260
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Keio University
• Principal Investigator: Fujita Harumi 慶應義塾大学, 医学部, 特任助教 (30736971)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: 皮膚 / 酸化ストレス / 鉄 / 表皮 / ヘム

Outline of Final Research Achievements

Heme Oxygenases (HOs) are heme-catabolizing enzymes known as cytoprotective molecules against oxidative stresses. We analyzed the expression and function of HO in the epidermis. HO-1 is specifically expressed in the uppermost layer of stratum granulosum, however, epidermal-specific HO-1/2 double knockout mice had no phenotype in both physiological and stressed conditions, e.g. UV irradiation and wound healing. These results suggested the function of HOs in epidermal development and stress regulation are compensated by other unidentified proteins. Now we are investigating the function of HO in the iron recycling in the epidermis.

Free Research Field

皮膚科学