2015 Fiscal Year Final Research Report
Analysis of autophagic impairment in neurons derived from familial parkinson's disease
| Project/Area Number |
26893263
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
|
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
|
| Keywords | パーキンソン病 / iPS細胞 / オートファジー |
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| Outline of Final Research Achievements |
PARK9-iPS cells were established from the patient's T-cell. We established a highly efficient induction method from the iPS cells into dopaminergic neurons. We found lysosomal abnormalities and impairment of autophagy in PARK9-dopaminergic neurons derived from iPS cells using the new induction method. We established mutation-corrected PARK9-iPS cell line using CRISPR/CAS9 system. We also detect abnormalities of mitopahagy in PARK2-dopaminergic neurons.
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| Free Research Field |
神経内科
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