2015 Fiscal Year Final Research Report
Elucidation of the regulatory mechanism of brain urate by urate transporters
| Project/Area Number |
26893275
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Keywords | 尿酸 |
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| Outline of Final Research Achievements |
Multiple urate transporters in the kidney are involved in the regulation of serum urate levels. In this study, we revealed that urate transporters are expressed in choroid plexus epithelial cells, ventricular ependymal cells which separates the ventricles and the parenchyma, and brain capillaries. By measuring the urate level in the cerebrospinal fluid (CSF), we revealed that urate in the CSF may be transported from the ventricle into the brain parenchyma by URAT1.
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| Free Research Field |
医歯薬学
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