2015 Fiscal Year Final Research Report
The nerve mechanisms underlying tongue-referred pain associated with tooth pulp inflammation in trigeminal ganglion cells
Project/Area Number |
26893288
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Conservative dentistry
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Research Institution | Nihon University |
Principal Investigator |
OHARA Kinuyo 日本大学, 歯学部, 専修医 (10731606)
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Project Period (FY) |
2014-08-29 – 2016-03-31
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Keywords | 歯髄炎 / 三叉神経節 / 異所性異常疼痛 |
Outline of Final Research Achievements |
The purpose of the present study is to evaluate the mechanisms underlying tongue-referred pain associate-ed with tooth pulp inflammation through TLR4 signaling in trigeminal ganglion cells. These results are the first documentation that TLR4 is involved in the ectopic tongue pain associated with M1TP inflammation. Following M1TP inflammation, Hsp70 is expressed in the pulpal tissues, transported to the cell bodies of the trigeminal ganglion neurons, or Hsp70 is expressed in TG cells, and then released from TG neurons innervating the inflamed M1TP. Hsp70 binds to TLR4 in TG neurons innervating the tongue, and the excitability of TG neurons innervating the tongue may be enhanced, resulting in ectopic tongue pain.
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Free Research Field |
歯内療法学
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