Analyse the effects of antimicrobe peptide Cathelicidin on dental pulp repair.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26893301
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Morphological basic dentistry
• Research Institution: Matsumoto Dental University
• Principal Investigator: Horibe Kanji 松本歯科大学, 歯学部, 助教 (70733509)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: 歯学 / 細胞・組織 / 生体分子 / 免疫学

Outline of Final Research Achievements

Cathelicidin is an antimicrobial peptide, binding to FPR2, and initiates various physiological actions. We examined the temporal localization of Cathelicidin and Fpr2 in rat tooth germ differentiation. In later bell stage, Cathelicidin was seen in odontoblasts and Fpr2-positive cells localized under odontoblasts. After tooth crown formation, Cathelicidin positive signals disappeared in crown odontoblasts, whereas Fpr2 positive signals were kept in subodontoblastic layer. Next we observed localization of Cathelicidin and Fpr2 in repair model of dental pulp tissues after cavity preparation. At 3 days after, Cathelicidin positive inflammatory cells were seen in the pulp under dental cavity. At 7 days, Cathelicidin and Fpr2 positive signals were detected in odontoblast contacting reparative dentin and cells under cavity.
These results suggest that Cathelicidin-FPR2 signal is involved in physiologic and reparative dentin formation.

Free Research Field

口腔解剖学