2015 Fiscal Year Final Research Report
Genetic features of pulmonary adenocarcinoma presenting with ground-glass nodules: the differences between nodules with and without growth
| Project/Area Number |
26893310
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory surgery
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Keywords | すりガラス様陰影 / ground glass nodule / ground glass opacity / 肺癌 / EGFR / CT |
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| Outline of Final Research Achievements |
Pulmonary ground-glass nodules (GGNs) include both malignant and benign lesions. Some GGNs become larger, whereas others remain unchanged for years. We have previously reported that smoking history and large diameters are predictors for growth. However, the genetic differences among GGNs remain unclear.
In this study we comprehensively investigate the genetic features of 104 GGNs in terms of targetable or potentially targetable driver mutations including EGFR, KRAS, ALK, and HER2. “Incidence of 2-mm growth” and “Time to 2-mm growth” were analyzed according to the mutational status. Three-fourths of resected GGNs were positive for EGFR, KRAS, ALK, or HER2 mutations. Quadruple-negative tumors were associated with GGNs with no growth, whereas EGFR mutation-positive tumors were correlated with growth. These results provide insight into the genetic features of GGNs and help establish reasonable follow-up algorithms to reduce radiation exposure and avoid unnecessary surgeries.
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| Free Research Field |
呼吸器外科
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