Effects of polyphosphate on inflammatory bone resorption: Development of novel treatment strategies for peri-implantitis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26893313
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Hiroshima International University
• Principal Investigator: HARADA Kana 広島国際大学, 薬学部, 助教 (90609744)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: ポリリン酸 / マクロファージ / リポポリサッカライド / IRF3 / STAT1

Outline of Final Research Achievements

The aim of this study was to investigate the effects of polyphosphate [poly(P)], a drug candidate for the treatment of peri-implantitis, on inflammatory bone resorption-related signal transduction. Poly(P) decreased the initial phosphorylation of STAT1 via suppressing IRF3 phosphorylation in macrophages activated with lipopolysaccharide, a cell wall component of Gram-negative bacteria. In addition, poly(P) was suggested to suppress the delayed phosphorylation of STAT1 in an IRF3-independent manner. These findings provide useful information for the development of novel treatment strategies for peri-implantitis.

Free Research Field

薬理学