2015 Fiscal Year Final Research Report
Molecular mechanism of synapse formed between neuron and oligodendrocyte precursor cell
| Project/Area Number |
26893316
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pharmacology in pharmacy
|
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| Research Institution | Fukuoka University |
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Principal Investigator |
|
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| Project Period (FY) |
2014-08-29 – 2016-03-31
|
| Keywords | neuroligin / oligodendrocyte |
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| Outline of Final Research Achievements |
Patients with autism spectrum disorder (ASD) demonstrate altered volume of white matter. But that mechanism is unknown. White matter is composed of oligodendrocytes. Therefore a function of neuroligin 3, which mutations of that gene is found in ASD, in differentiation of oligodendrocyte precursor cell (OPC) was examined. OPC expressed neuroligin 3 and responded to glutamate via AMPA type glutamate receptor. Function of neuroligin 3 in OPC differentiation because expression level of neuroligin 3 could not be regulated using gene transfection. We should modify experimental condition.
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| Free Research Field |
神経薬理学
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