Pharmacological approaches for the suppression of scar formation after palatoplasty in a wound-healing model

2015 Fiscal Year Final Research Report

• Project/Area Number: 26893320
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Fukuoka Dental College
• Principal Investigator: Hata Shozaburo 福岡歯科大学, 口腔歯学部, 助教 (40736732)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: 歯科矯正学 / 創傷治癒 / 筋線維芽細胞

Outline of Final Research Achievements

Scar formation after palatoplasty is considered to inhibit maxillary growth and dento-alveolar development. Transforming growth factor-β1 (TGF-β1) reportedly causes the differentiation of fibroblasts toward cells possessing a contractile phenotype (myofibroblasts) during wound-healing. The aim of this study is to clarify the mechanism underlying the activation of TGF-β1 in efforts to identify promising pharmacological approaches for the suppression of scar formation. As a result, a TGFβ type I receptor inhibitor appears to be effective in inhibiting the myofibroblastic differentiation, and may be a possible therapeutic approach for the suppression of scar formation.

Free Research Field

歯科矯正学