Understanding for the induction mechanisms of intestinal IL22-producing cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 26893326
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Tanoue Takeshi 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 基礎科学特別研究員 (60732972)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: IL22 / 腸内細菌

Outline of Final Research Achievements

In this study, I focused on interleukin (IL)22-producing cells, which are considered to be a key player in protection against gastrointestinal infection. First, I’ve analyzed the numbers of IL22-prodcing cells in various tissues of healthy mice. As a result, IL22-producing cells were abundant in gut, especially in the small intestine. In contrast to microbiota-harboring SPF (specific pathogen free) mice, germ-free mice showed substantially lower numbers of the cells, suggesting gut microbiota induce the accumulation of IL22-producing cells. Furthermore, I found that type3 innate lymphoid cells are main cellular source of IL22 and gram-positive ingenious members induce the IL22+ ILC3.

Free Research Field

免疫学、微生物学