1985 Fiscal Year Final Research Report Summary
Preparation of carbon dental implant with fine Rahmen surface layer and observation of its biological response
| Project/Area Number |
58870093
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
補綴理工系歯学
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
1983 – 1985
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| Keywords | Carbon dental implant / Fine-Rahmen-surface layer / Low temperature pyrolytic carbon / Tissue culture / Cell affinity / Bone-derived cell / Shear-attachment strength / 骨形成 |
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| Research Abstract |
A new carbon dental implant with a fine Rahmen surface structure (FRS carbon implant) which possibly produce a functional attachment to the living tissues was proposed by the authors. The implants were prepared by fixing FRS-layer of carbon fabric on a carbon fider-reinforced carbon core. The fixing was successfully performed theough the low-temperature deposition of pyrolitic carbon. The resultant implants showed flexural and compressive strength more than 150 and 100 MPa, respectively. The outer part of this FRS layer contained many pores ranging from 30 to 300 um in diameter and 40 to 75 % in volume fraction.
Tissue culture study and animal experiments:
(1). FRS carbon implants exert no negative effect on colony-forming ability, the population-doubling time of L 1210, Sq 79, and L181 cells. The bonederived cells from 18 day fetus rat calvaria proliferated to form a rissue matrix within the spaces of the FRS layer.
(2). Enbeded FRS carbon implants into the healthy Macaca fuscata showed shearattachment strength at 2 months after oparation was more than 100 kg/ <cm^2> , then increased to 238 kg/ <cm^2> in 7 months after oparation. While the shear-attachment strength of cylinder type carbon implant without FRS layer was 11.9 kg/ <cm^2> at 2 months after oparation.
(3). Seven months after the operation, bone growth into the FRS layer reached about 400 um in depth. This interface areas between the implant and the peripheral tissues and ingrown tissues within the FRS implants were observed.
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