1986 Fiscal Year Final Research Report Summary
Molecular Mechanism of Steroid Hormone Action and Modulation of Gene Expression
| Project/Area Number |
59370011
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
SAKAMOTO Yukiya Osaka Univ., Medical School, Professor, 医学部, 教授 (60028280)
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| Co-Investigator(Kenkyū-buntansha) |
ENDO Hiroyoshi Teikyo Univ., Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (50012604)
村山 昭 東京都臨床医学総合研究所, 主任研究員 (10109952)
OTA Minoru Iwate Medical Univ., School of Dentistry, Professor, 歯学部, 教授 (70048255)
ICHIHARA Akira Univ. of Tokushima, School of Medicine, Professor, 医学部, 教授 (40035374)
ICHII Shogo Tottori Univ., School of Medicine, Professor, 医学部, 教授 (80032150)
MURAYAMA Akira Tokyo Metropolitan Inst. of Med. Sci., Chief Researcher (40035374)
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| Project Period (FY) |
1984 – 1986
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| Keywords | Steroid Hormone Receptor / Glucocorticoid / Testosterone / Estrogen / Progesterone |
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| Research Abstract |
An intensification in the study of steroid hormone receptors and their molecular mechanisms of aciton has resulted in a great deal of information on how the steroid hormones stimulate cells by controlling the synthesis of particular protein. However, the primary structure of the steroid hormone receptors and their subunits, and the modulators or receptor functions, and regulation of gene expression have not previously been elucidated. Thus, this research project was organized to further the understanding and elucidation of the molecular mechanism of steroid hormone action which underlies the physiological process.
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