1986 Fiscal Year Final Research Report Summary
Integrative studies on the thermosensitivity of living body and the onset of thermoregulatory responses.
| Project/Area Number |
59440026
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
環境生理学(含体力医学･栄養生理学)
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| Research Institution | Osaka University Medical School |
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Principal Investigator |
NAKAYAMA TERUO Prof. Dept of Physiol. Osaka Univ Med Sch, 医学部, 教授 (80022763)
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| Co-Investigator(Kenkyū-buntansha) |
TAMAKI YOKO Res. Assoc. Dept of Physiol. Osaka Univ Med Sch, 医学部, 助手 (60141602)
TANAKA HIDETO Res. Assoc. Dept of Physiol. Osaka Univ Med Sch, 医学部, 助手 (60163557)
MATSUMURA KIYOSHI Res. Assoc. Dept of Physiol. Osaka Univ Med Sch, 医学部, 助手 (10157349)
KANOSUE KAZUYUKI Res. Assoc. Dept of Physiol. Osaka Univ Med Sch, 医学部, 助手 (50127213)
ISHIKAWA YOUZOU Assoc. Prof. Dept of Physiol. Osaka Univ Med Sch, 医学部, 助教授 (50028643)
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| Project Period (FY) |
1984 – 1986
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| Keywords | Thermoregulation / Hypothalamus / Thermosensitive neuron / Brown adipose tissue / Respiratory gases / Saliva secretion / Intracranial self-stimulation / 運動 |
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| Research Abstract |
1. Studies on thermosensitive neurons. (1) Activities of supraoptic and para-ventricular neurosecretory cells were facilitated by preoptic warming. (2) Scrotal warming in rats produced not only thermoregulatory responses but also non-specific responses such as EEG desynchronization. (3) Warm-sensitive neurons showing on-off type response at higher brain temperature were found in the posterior hypothalamus. (4) <CO_2> stimulated thermosensitive neurons in vivo, but depressed in vitro.
2. Studies on thermoregulatory effectors. (1) Temperature signals generated in the preoptic area were transmitted to the hypothalamic ventromedial nucleus, which controlled brown adipose tissue thermogenesis. (2) Saliva secretion in anesthetized rats were observed at various experimental conditions. Central and peripheral temperature signals were integrated to produce salivation. Preoptic warming produced saliva secretion and body extension, while warming of the posterior hypothalamus caused grooming. (3) Intracranial self-stimulation with loaded bar press was observed at various internal and external thermal stresses. (4) Rectal temperature of rats running on a treadmill increased in proportion to the exercise intensity.
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