1985 Fiscal Year Final Research Report Summary
Study on new dynamic classification of sleep and the its clinical application.
| Project/Area Number |
59440051
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Tokyo Metropolitan Institute for Neuroscience |
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Principal Investigator |
AZUMI Kazuo (財)東京都神経科学総合研究所, その他, 研究員 (90073056)
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| Project Period (FY) |
1984 – 1985
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| Keywords | new dynamic classification of sleep / spindle-enhancing phase / spindle-modifying phase / REM sleep phase / delta component integration pattern / 短時間覚醒による増加修飾 / 低帯域成分波積分パターン / 両期の差違 |
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| Research Abstract |
A. Purpose: The classification of the human sleep states by method of Rechtschaffen and Kales (1968) takes root due to practical convenience. The weak points, however, exist in being not able to quantitatively analyze or estimate stages 3 ＆ 4 NREM sleep due to complication of delta EEG wave form. Since, further, This method does not allow to discriminate time-dependent changes of NREM sleep, one of NREM sleep stages used to suddenly change to another one of NREM stages. In this study, by using spindle appearance number and delta EEG wave component integration value, we intend to classify sleep states or sleep course across night, quantitatively and continuously. Then this classification will be used to study of sleep disturbances with pseudoneurotics and /or psychotics.
B. Results: For an investigation of sleep phase classification, 21 healthy male adults, aged 18-25 years, were studied with routine sleep polygraphic recordings during 7 consecutine nights. The definition of a spindle wa
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s taken as"at least 6 consecutive waves which range from 11-16 Hz and reach over 10 <micro> V in amplitude". By counting spindle number the spindle appearance pattern was made automatically by microcomputer. As same way, delta EEG component with 1-2 Hz were continuously integrated with a epoch of 30 seconds.
Each sleep cycle was divided before and after the peak of spindle appearance pattern. The former is spindle-increasing phase, and the latter is spindle-modifying phase. The increasing phase is covered only by stage 2 and has characteristics of longer spindle duration, of gradual extension as time goes by, and of more incidence of minor body movement. The modifying phase is occupied by all kinds of NREM sleep and shows a shortening tendency of spindle duration, gradual reduction in the length as time goes by, and more appearance of major body movement. Peaks of the smoothed delta integration pattern were mostly found at the early time in the modifying phase and they appeared within 20-30 minutes on the average . We expect that a questionable or unnatural sleep would be discriminated by using a new sleep phase classification. Less
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