1986 Fiscal Year Final Research Report Summary
Epidemiological and clinical studies of sexually transmitted diseases (STD)
Grant-in-Aid for General Scientific Research (A)
|Allocation Type||Single-year Grants |
|Research Institution||Sapporo Medical College |
KUMAMOTO Yoshiaki Sapporo Medical College, 医学部, 教授 (40045323)
OKAYAMA Satoru Sapporo Medical College, 医学部, 助手 (70128510)
HIROSE Takaoki Sapporo Medical College, 医学部, 助手 (80136960)
SAKAI Shigeru Sapporo Medical College, 医学部, 講師 (20117625)
|Project Period (FY)
1984 – 1986
|Keywords||one shot therapy in gonococcal infections / measurement of IgA & IgG antibody of C. trachomatis / HPV-1 and HPV-2 in genital herpes / 尖型condylomaのHPV-6、11及び16|
Epidemiological survey is very important to understand how sexually transmitted diseases (STD) is now prevalent in Japan. However, reliable statistics on incidence rate of STD was not made by Governmental Office. Then we tried to collected as many case-records of various STDs as possible, from all over Japan. 20,000 cases of STD were collected mainly from urological clinics, partly from gynecological clinics calculated relative incidence rate of each STD to gonorrhoeae was as follows (for reference, same statistics in U.S.A. is added).
Gonorrhoeae: 100 (100), Nongonococcal urogenital infection: 145, (Chlamydial trachomatis infection): 100 (150), Genital warts: 26.7 (50), Genital herpes: 16.1 (2.5), Initial syphilis: 7.6 (4.5)
To compare to U.S.A.'s data, chlamydial and viral STDs in Japan have about half values in relative incidence rate to gonorrhoeae. This results revealed that Japan still stands in the retarded situation in concerned of STD prevalence. However, positive rate of chlamy
dia trachomatis from cervix of pregnant house-wives has reached already to same level of U.S.A., that is 6-7%. And also we confirmed the increasing tendency of number in viral STD cases.
These findings mean that STD prevalence in Japan is now going rapidly to catch up to U.S.A.'s level. However, the most important problems that we now have is that the diagnostic techniques of chlamydia trachomatis are not yet so popular among first-line doctors, routingly treated those cases. We suppose that the incidence of STDs in Japan will remarkably rise up and may be reach close to U.S.A. level, if these techniques prevalate all such doctors.
Studies on clinical aspects of various STDs were also done. Important results in these studies are as follows.
1) All isolation rate of PPNG in Sapporo is 18.5%. All plasmid of PPNG isolated in Sapporo are the south-east asian type.
2) Assays of IgA & IgG antibodies value for chlamydial trachomatis have significance as the means of epidemiological survey, but not as the acurate diagnostic technique.
3) Immunofluorescent direct speciment test for herpes simplex virus can identified the virus in only half cases which are isolated virus by culture technique. This data revealed that the culture is necessary to diagnose genital herpes cases. Less
Research Products (10 results)