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1986 Fiscal Year Final Research Report Summary

Central interaction between thermoregulation and osmoregulation.

Research Project

Project/Area Number 59480113
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 環境生理学(含体力医学・栄養生理学)
Research InstitutionSaga Medical College

Principal Investigator

KIYOHARA Toshikazu  Saga Medical College, 医学部, 助教授 (50071874)

Co-Investigator(Kenkyū-buntansha) KOGA Hisao  Saga Medical College, 医学部, 助手 (30153513)
YAMASAKI Mari  Saga Medical College, 医学部, 助手 (80174647)
NAKASHIMA Toshihiro  Saga Medical College, 医学部, 助手 (30128136)
SHIBATA Masaaki  Saga Medical College, 医学部, 助手 (00128133)
HORI Tetsuro  Saga Medical College, 医学部, 教授 (00022814)
Project Period (FY) 1984 – 1986
KeywordsHypothalamus / Thermosensitive neuron / Thermoregulation / Osmosensitive / Osmoregulation / Water balance / Central interaction / Baro
Research Abstract

To analyze the possible central interaction between thermoregulation and osmoregulation, we have investigated the effect of osmotic and blood pressure changes on the activities of thermosensitive neurons in the preoptic an anterior hypothalamus (PO/AH) where are known to play a cardinal role in thermoregulation.
1. About 60% of PO/AH thermosensitive neurons tested are osmosensitive. Some PO/AH neurons responded to both local an peripheral osmotic sitmuli. The major response pattern was the decreased firing rate of warm sensitive neurons to hyperosmotic stimuli given either locally or peripherally. The reduced activity of PO/AH warm sensitive neurons in a hyperosmotic environment may appropriate to explain, at least in part, the phenomenon of reduced evaporative heat loss in dehydrated mammals.
2. Falls in blood pressure increased and decreased the activity of warm sensitive neurons and cold sensitive neurons respectively. Bilateral denervation of glossopharyngeal, vagus and sympathetic nerve abolished the neuronal responses to blood pressure changes. These neuronal responses during hypotension suggest that at least a part of hypothermia observed during acute hemorrhage in a centrally induced response having a survival value.
3. The unit activities of PO/AH thermosensitive neurons in free-moving rats were modified by not only thermoregulatory behaviors but also non-thermoregulatory behaviors.
4. The results suggest that PO/AH thermosensitive neurons, beside their postulated thermoregulatory functions, might be involved in the coordination of thermoregulation with non-thermal homeostatic functions controlled in the hypothalamus.

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Toshihiro Kiyohara: Thermal physiology. 141-144 (1984)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toshikazu Kiyohara: J.Therm.Biol.9. 21-26 (1984)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toshihiro Nakashima: Pflugers Archiv. 405. 112-117 (1985)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tetsuro Hori: Brain Research Bulletin. 17. 75-82 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hisao Koga: Brain Research Bulletin. (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hisao Koga: Brain Research Bulletin. (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toshikazu Kiyohara: "Neural inputs to preoptic thermosensitive neurons - histological and electro-physiological mapping of central connections." J. Therm. Biol.9. 21-26 (1984)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toshihiro Nakashima: "Osmosensitivity of preoptic thermosensitive neurons in hypothalamic slices in vitro." Pflugers Archiv. 405. 112-117 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tetsuro Hori: "Responsiveness of monkey preoptic thermosensitive neurons to non-thermal emotional stimulation." Brain Research. 17. 75-82 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hisao Koga: "Responses of preoptic thermosensitive neurons to changes in blood pressure." Brain Research Bulletin. (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hisao Koga: "Convergence of hepatoportal osmotic and cardiovascular signals on preoptic thermosensitive neurons." Brain Research Bulletin. (1987)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1988-11-10  

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