1988 Fiscal Year Final Research Report Summary
Studies on the interaction between intracellular protozoa and macrophages from athymic nude (rnu/rnu) rat and the littermate (rnu/+)
| Project/Area Number |
59570175
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
寄生虫学(含医用動物学）
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
1984 – 1988
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| Keywords | Nude rat (rnu / rnu) / Trypanosoma cruzi / Macrophage / Lysosome |
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| Research Abstract |
5. The amount of oxygen radicals was measured and compared between macrophages from the nude rats and the littermates. The oxygen radicals were determined utilizing a luminol-mediated chemiluminescence. The amount was found approximately 10 times more in macrophages of the littermates, when stimulated with FMLP or viable trypomastigotes of T. cruzi. The velocity of production of oxygen radicals was also faster in the macrophages from the littermates. The similar data have been also obtained with Leishmania.
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