1986 Fiscal Year Final Research Report Summary

An experimental study on the antigenicity of inorganic ceramics using as biomaterials.

Research Project

Project/Area Number	59570631
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	Orthopaedic surgery
Research Institution	Gunma University School of Medicine
Principal Investigator	UDAGAWA Eiichi Dept. Orthop. Gunma University School of Medicine, 医学部, 教授 (70009976)
Co-Investigator(Kenkyū-buntansha)	CHIGIRA Masaki Dept. Orthop. Gunma University School of Medicine, 医学部, 助手 (70143196)
Project Period (FY)	1984 – 1986
Keywords	Biomaterials / Ceramics / Antigenicity / Immunogenitics / Oxidation-reduction reaction / Loosening / Inflammation / 吸着
Research Abstract	Significant footpad swelling was observed in mice immunized with tricalcium phosphate ceramic at 2 and 4 weeks after immunization. Antigenic specificity was demonstrated in cross-over design. Time course of the reaction suggest that delayed-type hypersensitivity played an important role. On the other hand, mice were died after administration of apatite-wollastonite glass ceramic. The death was induced by the ceramic powder itself, and was not induced by the supernatant of the powder. Significant footpad swelling showed the presence of delayed-type hypersensitivity against apatite-wallostonite. The adsorption behavior of cytochrome c on silica obeys the Langumuir adsorption irotherm. Furthermore, silica induced electron transfer of cytochrome c.