1986 Fiscal Year Final Research Report Summary
Development of Artificial <beta> cell
| Project/Area Number |
59870043
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
ICHIHASHI Hidehito Nagoya University School of Medicine, Associate Professor, 医学部, 助教授 (30023766)
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| Co-Investigator(Kenkyū-buntansha) |
河合 義雄 呉羽化学工業株式会社, 東京研究所, 研究主幹
MORI Yuichi Toray Industries, Inc. Basic Research Laboratories, Chief Researcher, 基礎研究所, 主任研究員 (10288003)
ITO Kaname Nagoya Institute of Technology Department of Applied chemisery, Professor, 教授 (50024196)
KAWAI Yoshio Kureha Chemical Industries Inc. Tokyo Laboratories, Chief Researcher
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| Project Period (FY) |
1984 – 1986
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| Keywords | Artificial pancreas / Subcutaneous glucose Sensor / Semipermeable membrane / Electron transfer nediator / ベンゾキノン |
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| Research Abstract |
The subcutaneous glucose sensors were prepared by using some glucose semipermeable membranes and tested in vitro under various oxygen tensions of 5 to 21 (%). They responded within 2 minutes at 95% of steady state and almost linearly up to 1500 mg/dl under 5% of oygen tension,they did linearly up to 500mg/dl by using the glucose semipermeable membranes which ristrict glucose penetration more seriously. And also needle type glucose sensors were prepared by using benzoquinone as an electron transfer mediator and tested in vitro and in vivo. Their outputs are unaffeted by oxygen tension in principle. Some reducing substances interfered the outputs. The outputs nearly corresponded to human plasma glucose levels. In IVGTT using normal dogs, the response values of outputs were smaller than those in vitro tests.
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