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1987 Fiscal Year Final Research Report Summary

Uniformity and specificity of function of monoaminergic receptors in the caudate nucleus and nucleus accumbens

Research Project

Project/Area Number 60440029
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionKyoto University

Principal Investigator

TAKAORI Shuji  Kyoto University, Faculty of Medicine, Professor, 医学部, 教授 (10025538)

Co-Investigator(Kenkyū-buntansha) AKAIKE Akinori  Kyoto University, Faculty of Medicine, Instructor, 医学部, 助手 (80135558)
FUJIWARA Motokazu  Kyoto University, Faculty of Medicine,Instructor, 医学部, 助手 (60093308)
SASA Masashi  Kyoto University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (20025654)
Project Period (FY) 1985 – 1987
KeywordsDepamine / Methamphetamine / Bromocriptine / Dopamine receptor / Nucleus accumbens / Caudate nucleus / Intracellular recording / イオントホレシス
Research Abstract

1. Electrophysiological study was performed to examine the actions of haloperidol and sulpiride on the nucleus accumbens neurons of rats receiving input form the parafascicular nucleus of thalamus, and to investigate whether or not the drugs antagonize the effects of exogenously applied dopamine and methamphetamine. The results indicated that exogenously applied dopamine as well as endogenously released dopamine produced an inhibition of the neuronal activities in the nucleus accumbens.
2. Methamphetamine also inhibited the nucleus accumbens neurons receiving input from the parafascicular nucleus of thalamus, probably by releasing dopamine form dopaminergic nerve terminals from the ventral tegmental area.
3. Microiontophoretic studies using anesthetized cats were performed to determine whether or not depamine D-1 and D-2 receptors co-exist in the same caudate nucleus neurons that receive inputs from the substantia nigra, and in which spikes elicited by nigral stimulation were blocked by domperidone, a selective D-2 antagonist. The results strongly suggested that the inhibitory D-1 and excitatory D-2 receptors co-exist on the same caudate neurons.
4. Effects of dopamine at low (1<mu>M) and high (100<mu>M) concentration on the rat caudate nucleus neurons were examined in a slice preparation using an intracellular recording technique. The results indicated that the postynaptic sites of caudate nucleus neurons have at least two subtype of dopamine receptors, D-1 and D-2 receptors, that mediate inhibitory and excitatory responses of the neuron to dopamine, respectively.
5. Effects of bromocriptine, a selective agonist for dopamine D-2 receptor, on the rat caudate nucleus neurons were examined in a slice preparation. The results implied that dopamine D-2 receptors activated by bromocriptine and a low concentration of dopamine mediated an excitation of the caudate nucleus neurons.

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Takaori,S.: Excerpta Medica International Congress Series. 743. 64-71 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hara,M.: Neuroscience Research. 4. 731-735 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohno,Y.: Life Sciences. 40. 1937-1945 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akaike,A.: Brain Research. 418. 262-272 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takatani,T.: Neuropharmacology. 26. 1389-1394 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohno,Y.: Life Sciences.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takaori, S.: "Electrophysiological study on action of antipsychotic drugs in the nucleus accumbens neurons." Excerpta Medica International Congress Series. 743. 64-71 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hara, M.: "Acute effects of methamphetamine applied microiontophoretically to nucleus accumbens neurons in rats." Neuroscience Research. 4. 731-735 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohno, Y.: "Coexistence of inhibitory dopamine D-1 and excitatory D-2 receptors on the same caudate nucleus neurons." Life Sciences. 40. 1937-1945 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akaike, A.: "Excitatory and inhibitory effects of dopamine on neuronal activity of the caudate nucleus neurons in vitro." Brain Research. 418. 262-272 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohno, Y.: "Excitatory effects of bromocriptine, a dopamine D-2 receptor agonist, on neuronal activity of caudate nucleus in vitor." Life Sciences. submitted.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1989-03-30  

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