1987 Fiscal Year Final Research Report Summary
nitrogen metabolism in liver disease
| Project/Area Number |
60440044
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Tottori University |
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Principal Investigator |
HIRAYAMA Chisato Department of Medicine, Tottori University School of Medicine, 医学部, 教授 (90037333)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Sadako Department of Medicine, Tottori University School of Medicine, 医学部, 教務員 (40150362)
KATO Seiichi Department of Medicine, Tottori University Hospital, 医学部附属病院, 助手 (10185845)
MURAWAKI Yoshikazu Department of Medicine, Tottori University School of Medicine, 医学部, 助手 (90144659)
HORIE Yutaka Department of Medicine, Tottori University School of Medicine, 医学部, 助手 (60144648)
SUOU Takeaki Department of Medicine, Tottori University Hospital, 医学部附属病院, 講師 (90108811)
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| Project Period (FY) |
1985 – 1987
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| Keywords | Liver cirrhosis / ^<15>N-glycine / Whole body protein turnover / branched chain amino acids / 3 methylhistidine |
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| Research Abstract |
In chronic liver disease, especially in liver cirrhosis, nitrogen balance tended to be nagative. We have studied whole-body protein turnover in control subjects and in patients with liver cirrhosis by a single oral dose of ^<15>N glycine. In control subjects, protein flux ranged from 2-4 g/LMBkg/day relating to dietary protein, but protein flux elevated to 4 g/LBMkg/day in patients with decompensated liver cirrhosis even under low protein diet. Rates of protein degradation were maintained about 2 g/LBMkg/day in control subjects regardless of dietary protein, and they were elevated to 3 g in patients with decompensated liver cirrhosis, indicating that whole-body turnover increased in patients with severe liver disease.
In patients with liver cirrhosis, plasma amino acid patterns show low branched chain amino acids, and urinary excretion of 3-methylhistidine is increased. In general, hyperglucagonemia and hyperinsulinemia have been postulated as factors responsible for alterations of amino acid metabolism, but such assumption has been denied. Because testosterone is known to be related to muscle protein metabolism, we have investigated the relationship between hypogonadism and altered amino acid metabolism in liver cirrhosis. Our study proved that plasma testosterone concentration correlated with plasma branched amino acid concentration and inversely with urinary 3-methylhistidine excretion, indicating that hypogonadism at least partly related to an augmented turnover of muscle protein and/or of whole-body protein.
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[Publications] Ohtake, H., Kato, S., Murawaki, Y., Kishimoto, Y., Wakushima, T., Hirayama, C.: "Acute and chronic effect of ethanol on hepatic albumin synthesis in rat liver in vitro" Res. Commun. Chem. Pathol. Pharmacol.53. 213-231 (1986)
Description
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