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1987 Fiscal Year Final Research Report Summary

FUNDAMENTAL AND CLINICAL RESEARCH ON THE RELATIONSHIP BETWEEN PULMONARY LYMPHATIC SYSTEMS AND THE PATHOGENESIS OF VARIOUS LUNG DISEASES

Research Project

Project/Area Number 60440062
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionSHIGA UNIVERSITY OF MEDICAL SCIENCE

Principal Investigator

OKADA Yoshio  SHIGA UNIVERSITY OF MEDICAL SCIENCE, VICE - PRESIDENT, DEAN OF UNIVERSITY HOSPITAL., 医学部・副学長附属病院長 (10106825)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Kentaro  SHIGA UNIVERSITY OF MEDICAL SCIENCE, RESEARCH ASSOCIATE, 医学部, 助手 (30171482)
KATO Hirofumi  SHIGA UNIVERSITY OF MEDICAL SCIENCE, LECTURER, 医学部, 講師 (20111974)
MORI Atsumi  SHIGA UNIVERSITY OF MEDICAL SCIENCE, ASSOCIATE PROFESSOR, 医学部, 助教授 (80026971)
Project Period (FY) 1985 – 1987
KeywordsPULMONARY LYMPHATIC SYSTEM / REGIONAL LYMPH NODES / LYMPHATIC METASTASTS OF LUNG / BRONCHUS-ASSOCIATED LYMPHOID TISSUE / DISSECTING OF METASTASIZED ABDOMINAL LYMPH DOGES / SELECTIVE LYMPHOGENOUS INJECTION OF ANTI-CANCER DRUGS
Research Abstract

The results of this research project are as the followings.
1. The study on the pulmonary lymphatic system of human fetus recognized us that the distribution and system of intrapulmonary lymphatic vessels were the same as Okada's report (1959). The descending route of lymphatics is as important as the ascending one. Abdominal lymphnodes capture the carbon and are metastasized by lung cancer through this route.
2. Immunohistochemical study on the bronchus-associated lymphoid tissue(BALT) of rats shows the distribution and dynamics of T-cell subpopulation in BALT. The ultrastructural study on BALT demonstrated high endothelial venule(HEV) plays the very important role as a gate through which macrophages and lymphocytes go in and out.
3. We proposed and performed agressively the dissecting of the contralateral mediastinal lymph nodes through the median sternotomy and the ultra-extended dissecting of intraabdominal lymph nodes.
4. Selective lymphogenous injection therapy by adriamycin, which was injected via the subpleural lymphatic vessels and via the subcarinal lymph nodes immediately after thoracotomy, is useful for controlling the micrometastasis. We proudced PLA(poly-lactic acid) microsphere containing aclacinomycin as a long retention type of drug.
5. The study on lung transplantation in rats shows clearly the dynamics of lymphocyte subsets in the lung and immune system organs. The lymphocyte subsets of peripheral blood and bronchoalveolar lavage fluid (BALF) change in correlation with the cell reaction in donor lung. In conclusion, the early diagnosis of rejection is possible by monitoring the blood and BALF.

  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 鈎 スミ子,岡田 慶夫: 医学のあゆみ. 133. 843-858 (1985)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岡田 慶夫,加藤 弘文,高橋 憲太郎: 呼吸. 5. 990-994 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岡田 慶夫 他5名: 日本胸部疾患学会雑誌. 24. 1124-1130 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshio Okada,et al.: J. Clin. Electron Microscopy. 19. 368-369 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岡田 慶夫: 日本リンパ系研究会. 10. 39-44 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 安田 雄司 他4名: 日本リンパ系研究会. 10. 144-147 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岡田 慶夫 加藤 弘文: "内科MOOK No.29 肺癌-肺癌の増殖と進展-" 金原出版株式会社, 12 (1985)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sumiko Magari, Yoshio Okada: "Current topics on the lymphatic system in the lung - Basic clinical problems in the mechanism of lymphogenic metastasis of lung cancer" IGAKU NO AYUMI. 133. 843-858 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshio Okada, Hirofumi Kato and Kentaro Takahashi: "Lymphatic system of the lung" Respiration Research. 5. 990-994 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshio Okada, Hirofumi Kato, Akira Yamanaka, Kentaro Takahashi, Shozo Fujino and Shuhei Inoue: "A Morphological Study on the Bronchus-Assoicated Lymphoid Tissue (BALT)" The Japanese Journal of Thoracic Diseases. 24. 1124-1130 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshio Okada, Kentaro Tkahashi, Hiorfumi Kato, Yuji Yasuda and Shoji Asakura: "Electron Microscopic Observation of Bronchus Associated lymphoid Tissue (BALT) in Normal and Allografted Rat Lungs" J. Clin. Electron Microscopy. 19. 368-369 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshio Okada: "DIAGNOSIS AND THERAPY FOR LYMPHATOGENOUS METASTASES OF LUNG CANCER" Japanise Journal of Lymphology. 10. 39-44 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoahio Okasa and Hirofumi Kato: Proliferation and Development of the Lung Cancer. NAIKA MOOK No. 29., 17-28 (1985)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1989-03-30  

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