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1988 Fiscal Year Final Research Report Summary

Development of New Immunotherapy in Ophthalmology

Research Project

Project/Area Number 60440079
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionUniversity of Tokyo

Principal Investigator

YAMASHITA Hidetoshi  Department of Ophthalmology, School of Medicine Univesity of Tokyo, 医学部(病), 講師 (90158163)

Co-Investigator(Kenkyū-buntansha) OHIRA Akihiko  Department of Ophthalmology, School of Medicine University of Tokyo, 医学部(病), 講師 (00114421)
ARAIE Makoto  Department of Ophthalmology, School of Medicine University of Tokyo, 医学部(病), 講師 (00092122)
MOCHIZUKI Manabu  Department of Ophthalmology, Tokyo University Branch Hospital, 医学部(分院), 助教授 (10010464)
MASUDA Kanjiro  Department of Ophthalmology, School of Medicine University of Tokyo, 医学部(病), 教授 (60010188)
Project Period (FY) 1985 – 1988
KeywordsUveitis / corneal transplantation / retinoblastoma / immunotherapy / cyclosporine / シクロスポリン / プロスタグランディンズ
Research Abstract

The present research project was aimed at developing new immunotherapies in opthalmology. For the treatment of uveitis, various immunosuppressants were tested in experimental autoimmune uveitis model and it was found that cyclosporine (CsA) had greate capacity to treat uveitis in the animal model. The agent was applied for the treatment of Behcet's disease with refractory uveitis. A total number of 69 patients with Behcet's disease who were resistant to conventional therapy were treated with CsA. The new therapy suppressed ocular attacks of the disease and the visual prognosis was much better than that of conventional hterapy, though CsA had some renal toxicity. CsC was also tested in animal model for its efficay in uveitis and it was found that CsC was effective to suppress uveitis in animals with much less renal toxicity. For the treatment of rejection of corneal transplantation, a new model for drug assay was established using rats. Penetrating keratoplasty was performed in inbred strains of rats having different MHC antigen. Using the model, the effects of CsA was assayed. For the treatment of retinoblastoma, monoclonal antibodies to retinobalstoma was established. Furthermore, effects of prostaglandins were eveluated using retinoblastoma cell line, Y-79 cells. PGD_2 and J_2 were found to have capacities to suppress retinoblastoma cells in vitro as well as in vivo. A monoclonal antibodies to retinoblastoma cell line, m-1131, was found to respond to fresh human retinoblastoma but not to other human tumors.

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 望月学,林清文,増田寛次郎: 日本眼科紀要. 38. 494-500 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujino Y;Okumura A;Nussenblatt RB;Gery I;Mochizuki M: Clin Immunol Immunopathol. 46. 234-248 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 川島秀俊,奥村敦司,藤野雄次郎,丹下剛,東原英二,堀内大太郎,望月学: 日本眼科学会雑誌. 91. 940-950 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura M;Fujino Y;Mochizuki M;Minoda K;Masuda K: Jpn J Ophtalmol. 31. 608-620 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 北川寛,大河内悦子,藤野雄次郎,泰順一,箕田健生,望月学,増田寛次郎: あたらしい眼科. 5. 1505-1509 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Herbort CP;Matsubara M;Nishi M;Mochizuki M: Jpn J Ophthalmol. (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mochizuki,M; Nussenblatt,RB;Kuwabara,T; Gey,I.: "Effects of cyclosporine and other immunosuppressive drugs on experimental autoimmune uveoretinitis in rats." Invest Ophthalmol Vis Sci. 26. 226-232 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mochizuki,M: "T-lymphocyte and experimental autoimmune uveoretinitis" Jpn J Ophthalmol. 31. 230-234 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujino,Y;Okamura,A;Nussenblatt,RB; Gery,I; Mochizuki,M: "Cyclosporine-induced specific unresponsiveness to retinal soluble antigens in experimental autoimmune uveoretinitis." Clin Immunol Immunopathol. 46. 234-248 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura,M;Koshihara,Y; Fujino,Y; Mochizuki,M; Minoda,K; Masuda,K.: "In vitro effects of prostaglandins on human retinoblastoma cell line, Y-79 cells." Jpn J Ophthalmol. 31. 598-607 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura,M;Fujino,Y; Mochizuki,M; Minoda,K; Masuda,K.: "In vivo effects of prostaglandins on human retinoblastoma cells in nude mice." Jpn J Ophthalmol. 31. 608-620 (1987)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1990-03-20  

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