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1988 Fiscal Year Final Research Report Summary

Basic and practical studies for management of oral bleeding in patients with hemophilia A von Willebrand's disease

Research Project

Project/Area Number 60440091
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field 外科・放射線系歯学
Research InstitutionNagoya University, School of Medicine

Principal Investigator

KANEDA Toshio  Department of Oral Surgery,Nagoya University,School of Medicine. Professor, 医学部, 教授 (30022768)

Co-Investigator(Kenkyū-buntansha) 河合 圭一  名古屋大学, 医学部, 医員
SUZUKI Hideharu  Department of Oral Surgery,Nagoya University,School of Medicine. Assistance, 医学部, 助手 (30187752)
SUMI Yasunori  Department of Oral Surgery,Nagoya University,School of Medicine. Assistance, 医学部, 助手 (30187801)
MATSUDA Masafusa  Department of Oral Surgery,Nagoya University,School of Medicine. Assistance, 医学部, 助手 (30136098)
TAKEUCHI Manabu  Department of Oral Surgery,Nagoya University,School of Medicine. Assistance, 医学部, 助手
KAWAI Keiichi  Department of Oral Surgery,Nagoya University,School of Medicine. Resident
Project Period (FY) 1985 – 1988
KeywordsHemophilia A / von Willebrand's disease / D.D.A.V.P. / von Willebrand factor antigen / Peroxidase-antioxidase complex method / Dental extraction / Oral bleeding / Lodal hemostatic management / High concentrated thrombin / ヘモグロビン測定法
Research Abstract

1) A high sensitive method for determination of hemoglobin applicable to quantitative analysis in oral bleeding. Elevation of sensitivity and development of new method.: We devised a modified cyanmethemoglobin method for determination of low concentrations of hemoglobin. In this method, absorption maximum at 420 nm having high molecular extinction coefficient was chosen, and sample volume was increased 100-fold. Thus, hemoglobin concentration could be correctly determined even in 10,000-fold diluted blood with saline.
2) Hemostatic effect of high-concentrate thrombin.: The high-concentrate thrombin preparations have excellent effectiveness for local hemostasis in patients with coagulopathies. In a practical clinical application of thrombin, it seems that plasms inhibitor and released heparinoid effect the preparation. Moreover, taking many kinds of plasma inhibitors into consideration, thes approach showed that clinically more than 1,000 units/ml thrombin was more effective.
3) Clinical … More study of the effect of DDAVP in oral hemorrhagic management with hemophilia A, von Willibrand disease patients and the like of factor VIII deficiency disease.: In all cases which factor VIII activity was more than 10% in preoperation data was effectively controlled with DDACP. And another cases which factor VIII activity was more than 4.5% in preoperation data was almost controlled with DDAVP and local hemostatic treatment. The last three cases of factor V and VIII deficiency disease was effectively controlled with DDAVP.
4) DDAVP and epinephrine-induced changes in the localization of von Willebrand factor antigen in endothelial cells of human oral mucosa.: After administration of epinephrine or DDAVP, the localization of vWF:Ag was shown to have changed to the basement membrane and the surrounding interstitum. This change of vWF:Ag localization induced by epinephrine and DDAVP may play a role in the adhesion of platelets to subendothelium following endothelial injury during surgery and may be unknown hemostatic effect of these drugs. Less

  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] SUZUKI,H.;et al.: Int.Associ.Oral Maxfac.Surg.,Proceedings from the 8th I.A.O.M.S.383-389 (1985)

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  • [Publications] SHIKIMORI,M.;et al.: Int.Associ.Oral Maxfac.Surg.,Proceeding from the 8th I.A.O.M.S.389-393 (1985)

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      「研究成果報告書概要(和文)」より
  • [Publications] SUZUKI,H.;et al.: J.Oral Maxillofac.Surg.43. 221-224 (1985)

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  • [Publications] SUMI,Y.;et al.: J.Oral Maxillofac.Surg.43. 382-384 (1985)

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  • [Publications] 鈴木英治 他: 血液と脈管. 16. 310-313 (1985)

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  • [Publications] 河合圭一 他: 日本口腔外科学会雑誌. 31. 1854-1858 (1985)

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  • [Publications] TAKEUCHI,M.;et al.: J.Oral Maxillofac.Surg.44. 401-403 (1986)

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  • [Publications] 竹内学 他: 血液と脈管. 17. 264-267 (1986)

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  • [Publications] 竹内学 他: 日本口腔科学会雑誌. 35. 104-110 (1986)

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  • [Publications] 松田匡房 他: 日本口腔科学会雑誌. 35. 99-103 (1986)

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  • [Publications] 河合圭一 他: 日本口腔外科学会雑誌. 32. 2195-2200 (1986)

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  • [Publications] 鈴木英治: 日本口腔外科学会雑誌. 32. 1164-1172 (1986)

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  • [Publications] SUZUKI,Hidearu; et dl.: "Local hemostatic procedure for teeth extractions in hemophiliacs without replacement therapy." International Association of Oral Maxillofacial Surgery, Proceeding from the 8th I.A.O.M.S.383-389 (1985)

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      「研究成果報告書概要(欧文)」より
  • [Publications] SHIKIMORI,Michio; et al.: "Clinical application of DDAVP for hemophilia and von Willebrand's disease." International Association of Oral Maxillofacial Surgery, Proceeding from the 8th I.A.O.M.S.389-393 (1985)

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      「研究成果報告書概要(欧文)」より
  • [Publications] SUZUKI,Hideharu; et al.: "Tooth extraction in two patients who had a congenital deficiency of factor X III." J. Oral Maxillofac. Surg.43. 221-224 (1985)

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  • [Publications] SUMI,Yasunori; et al.: "Multiple extractions in a patient with factor VII deficiency." J. Oral Maxillofac. Surg.43. 382-384 (1985)

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  • [Publications] SUZUKI,Hideharu; et al.: "Hemostatic effect of high-concentrate thrombin" J. Blood and Vessel. 16. 310-313 (1985)

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      「研究成果報告書概要(欧文)」より
  • [Publications] KAWAI,Keiichi;et al.: "A high sensitive method for determination of hemoglobin applicable to quantitative analysis in oral bleeding." Jpn. J. Oral Maxillofac. Surg.31. 1854-1858 (1985)

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  • [Publications] TAKEUCHI,Manabu; et al.: "Life-threatening sublingual hematoma in a severely hemophilia patient with factor vII inhibitor." J. Oral Maxillofac. Surg.44. 401-403 (1986)

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  • [Publications] TAKEUCHI,Manabu; et al.: "Immunocytochemical analysis of factor VII related antigen (von Willebrand factor) localization in the human endothelium after the treatment with vasoactive drugs. An ultrastructural study." J. Blood and Vessel. 17. 264-267 (1986)

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  • [Publications] TAKEUCHI,Manabu; et al.: "Clinical and immunocytochemical analysis of factor VII related antigen localization in the human endothelium." J. Jpn. Stomatol. Soc.35. 104-110 (1986)

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  • [Publications] MATSUDA,Masafusa; et al.: "Clinical study of DDAVP for oral bleeding procedures in patient with hemophilia A and von Willebrand's disease." J. Jpn. Stomatol. Soc.35. 99-103 (1986)

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  • [Publications] KAWAI,Keiichi; et al.: "A high sensitive method for determination of hemoglobin applicable to quantitative analysis in oral bleeding, II.Elevation of sensitivity and development of a new gargling method for sample preparation." Jpn. J. Oral Maxillofac. Surg.32. 2195-2200 (1986)

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  • [Publications] SUZUKI,Hideharu; et al.: "The effect of high-concentrate thrombin on coagulation and fibrinolysis." Jpn. J. Oral Maxillofac. Surg.32. 1164-1172 (1986)

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  • [Publications] KAWAI,Keiichi; et al.: "The study of oral haemorrhagic management in patients with blood disease." Jpn. J. Oral Maxillofac. Surg.63. 274-278 (1986)

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  • [Publications] YOSHIDA,Kunio; et al.: "Hemostatic efficacy of l-deamino-8-D-arginine (DDAVP) in patients with hemophilia A and von Willebrand's disease." Clinic and Research. 63. 1385-1402 (1986)

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  • [Publications] TAKEUCHI,Manabu; et al.: "The study of oral hemorrhagic management in patients with blood disease The XI seriese the management of oral bleeding in two patients with congenital deficiencies of both factor V and VIII." Jpn. J. Oral Maxillofac. Surg.33. 760-763 (1987)

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  • [Publications] TAKEUCHI,Manabu; et al.: "DDAVP and epinephrine-induced changes in the localization of von Willebrand factor antigen in endothelial cells of human oral mucosa." Blood. 72. 850-854 (1988)

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  • [Publications] MATSUDA,Masafusa: "Clinical study of the effect of DDAVP in oral hemorrhagic management with hemophilia A, von Willebrand's disease patients and like of factor VII deficiency disease." Jpn. J. Oral Maxillofac. Surg.(1989)

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Published: 1990-03-20  

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