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1988 Fiscal Year Final Research Report Summary

Control of feeding behavior and processing of hierarchial humoral information through the central and peripheral chemosensitive systems.

Research Project

Project/Area Number 60440097
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field 医学一般
Research InstitutionKyushu University

Principal Investigator

OKUKADO Nobuhisa  Faculty of Science, Kyushu University, 理学部, 助教授 (40037213)

Co-Investigator(Kenkyū-buntansha) SAKAI Kiyoshi  Faculty of Pharmaceutical Sciences, Kyushu University, 薬学部, 教授 (90153840)
SAKATA Toshiie  Faculty of Medicine, Kyushu University, 医学部, 助教授 (50037420)
SHIMIZU Nobuaki  Faculty of Medicine, Kyushu University, 医学部, 講師 (50019634)
OOMURA Yutaka  Faculty of Science, Kyushu University, 名誉教授 (30019517)
Project Period (FY) 1985 – 1988
KeywordsEndogenous chemical substance / Feeding behavior / Lateral hypothalamic area / Ventromedial hypothalamic nucleus / Chemosensitive neuron / 3,4-dihydroxybutanoic acid / 2,4,5-trihydroxypentanoic acid / 孤束核
Research Abstract

Three endogenous chemical substances, such as 3,4-dihydroxybutanoic acid (3,4-DB), 2,4,5-trihydroxypentanoic acid (2,4,5-TP) and 2-buten-4-olide (2-B40) were identified in blood under normal conditions of rats. Their concentrations were demonstrated to be increased following food deprivation. Injection of 3,4-DB or 2-B40 into the IIIed ventricle induced anorexia in rats, while injection of 2,4,5-TP provoked feeding behavior. The mechanisms of central actions of these substances were investigated. Intracellular recordings were made from neurons in the lateral hypothalamic area (LHA) and ventromedial hypothalamic nucleus (VMH), brain areas referred to as feeding and satiety centers, respectively. The LHA meurons hyperpolarized by 3,4-DB showed no change in membrane input resistance, while the depolarized VMH neurons were associated with an increase in membrane resistance. The effect of 2-B40 was similar to that of 3,4-DB. 2,4,5-TP depolarized LHA neurons but hyperpolarized VMH neurons with a decrease in the membrane resistance. The results of this study indicated that 3,4-DB and 2,4,5-TP have reciprocal effects on each LHA and VMH neurons, and provide further evidence for the roles of these three chemicals as endogenous feeding modulatory substances.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Nishimura,H.: J.Neurophysiol.58. 655-675 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Oomura,Y.: News Physiol.Sci.2. 199-203 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Plata-Salaman,C.R.: Brain Res.448. 106-114 (1988)

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      「研究成果報告書概要(和文)」より
  • [Publications] Minami,T.: Brain Res.462. 258-264 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukuda,A.: Am.J.Physiol.255. 134-140 (1988)

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      「研究成果報告書概要(和文)」より
  • [Publications] Uchikawa,O.: Bull.Chem.Soc.Jpn.61. 2025-2029 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Oomura,Y.: "Control of food intake and hypothalamic activity by endogenous chemical substances.Recent Advances in Obesity Research." John Libbey & Co.Ltd./London, 229-245 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Oomura,Y.: "Regulation of alimentation by sugar acids in body fluids.In:Diet and Obesity." Japan Sci.Soc.Press, 3-15 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uchikawa, O.: "Synthesis of ( S)- and (R)-3-hydroxy-4-butanolide and (2S,4S)-, (2R,4S)-, (2S,4R)-, and (2R,4R)-2-hydroxymethyl-4-butanolide and their satiety and hunger modulating activities." Bull. Chem. Soc. Jpn.61. 2025-2029 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oomura, Y.: "Regulation of feeding by neural responses to endogenous factors." News Physiol. Sci.2. 199-203 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Plata-Salaman, C.R.: "Tumor necrosis factor and interleukin 1 : Suppression of food intake by direct action in the central nervous system." Brain Res.448. 106-114 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Minami, T.: "Direct effects of 3,4-dihydroxybutanoic acid -lactone and 2,4,5-trihydroxypentanoic acid -lactone on lateral and ventromedial hypothalamic neurons." Brain Res.462. 258-264 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukuda, A.: "A novel endogenous sugar acid depolarizes ventromedial hypothalamic neurons in vitro." Am. J. Physiol.255. 134-140 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oomura, Y.: Control of food intake and hypothalamic activity by endogenous chemical substances. Recent Advances in Obesity Research.Japan Sci. Soc. Press, 229-245 (1987)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1990-03-20  

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