• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1987 Fiscal Year Final Research Report Summary

Development of Photodynamic Therapy for Malignant Tumors

Research Project

Project/Area Number 60440111
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionTOKYO MEDICAL COLLEGE

Principal Investigator

HAYATA Yoshihiro  Dept. of Surgery, Tokyo Medical College Professor, 医学部, 教授 (30074470)

Co-Investigator(Kenkyū-buntansha) KAWATA Norihiko  Dept. of Surgery. Tokyo Medical Colledge Assistant, 医学部, 助手 (70204740)
米山 一男  東京医科大学, 医学部, 助手
KONAKA Chimori  Dept. of Surgery, Tokyo Medical College Assistant, 医学部, 助手 (70147180)
AIZAWA Kastuo  Dept. of Physiology, Tokyo Medical College Assistant Professor, 医学部, 助教授 (40074645)
KATO Harubumi  Dept. of Surgery, Tokyo Medical Colledge Lecturer, 医学部, 講師 (20074768)
YONEYAMA Kazuo  Dept. of Surgery, Tokyo Medical Colledge Assistant
Project Period (FY) 1985 – 1987
KeywordsPhotodynamic therapy / Photosensitizer / Mono-L-aspartyl / chlorin e6 (NPe6) / Hematoporphyrin derivative (HpD) / Excimer dye laser Mitochondria / ミトコンドリア / ビデオ顕微鏡
Research Abstract

Photodynamic therapy (PDT) is based on incorporation of a photosensitizer that has high affinity for malignant tissue and stimulation of the photosensitizer with a low power laser beam, with tumorcidal effects. Using the same principle fluorescence can also be elicited from the tumor by a laser beam of a different wavelength in order to detect the lesion. Our team has investigated this therapeutic modality in basic and clinical studies for ten years. Our initial studies employed hematoporphyrin derivative (HpD) as the photosensitizer for PDT with an argon dye laser and we have reported the first cases of five-year survival in a case of cancer treated only by PDT.
Mono-L-aspartyl chorin e (NPe ) is a photosensitizer newly developed in 1987. This material shows higher affinity to tumor and better light absorption than HpD. It has a strong absorption band at a wavelength longer than 600nm and consequently is not affected by hemoglobin. Further investigations are necessary for clinical application.
An excimer dye laser which more powerful than the argon dye laser has been developed for clinical applications. This laser equipment makes it possible to diagnose and treat in the same procedure by a wavelength-change device. Especially for diagnoses, the fiberscopic image, fluorescent light, and fluorescent wave length are shown in the same image.
The basic experiment of photodynamic therapy has been performed. HpD and NPe have been shown to have a high affinity for mitochondria. Damage to the mitochondria by photosensitizer was recognized by decrease in mitochondrial movement. This is in agreement with theories that the first step of photodynamic therapy is degeneration of mitochondria.
In 1987 the basic investigation, the laser equipment and the newly developed photosensitizer for photodynamic therapy were established. Our proposed project is a clinical trial and comparison with PDT using HpD and argon dye laser, as well as with other modalities.

  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 早田 義博 他: BME. 1. 532-535 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 早田 義博 他: 外科診療. 29. 1155-7161 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 早田 義博 他: 呼吸. 6. 1041-1053 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 加藤 治文 他: BME. 1. 532-535 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 加藤 治文 他: 日本臨床 特集:レーザー医学の進歩. 45. 126-131 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 會沢 勝夫 他: Photochemistry and Photobiology. 46. 789-793 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 早田 義博 他: "肺癌〈臨床visoal Mook 1〉" 全日本病院出版会, 216 (1985)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshihiro Hayata et al.: "Photodynamic therapy in excimer dye laser" BME. 1. 532-535 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshihiro Hayata et al.: "Laser surgery" Surgical examination (Geka Shinryo). 29. 1155-1161 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshihiro Hayata et al.: "Lung cancer examination (Haigan Kenshin)" Respiration (Kokyu). 6. 1045-1053 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Harufumi Kato et al.: "Lung cancer-Photodynamic Therapy-" Nihon Rinsho. 45. 126-131 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Katuo Aizawa: "Localization of mono-L-aspartyl chlorin e6 (NPe6) in mouse tissues" Photochemistry and Photobiology. 46. 789-793 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshihiro Hayata et al.: Lung cancer @clinical Visual Mook 1>. Zen Nihon Byouin Shuppan Kai, 216 (1985)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1989-03-30   Modified: 2017-04-05  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi