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1987 Fiscal Year Final Research Report Summary

An analysis of connexions between 2nd and 3rd order of relay neurones in the spinal reflex.

Research Project

Project/Area Number 60480104
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 神経解剖学
Research InstitutionUniversity of Toky

Principal Investigator

SASAKI Shigeto  University of Toky, Associate Professor, 医学部, 助教授 (50110490)

Co-Investigator(Kenkyū-buntansha) KANEMITSU Akira  University of Toky, Professor, 医学部, 教授 (70108281)
Project Period (FY) 1985 – 1987
KeywordsBrain Stem Reticular Formation / Neck Motoneurones / Cerebral Cortex / Neck Movement / 上丘
Research Abstract

Dorsal neck motoneurones innervationg splenius (SPL) and biventer cervicis and complexus (BCC) muscles receive disynaptic excitatory effects after stimulation of the tectum and the pyramid in the cats. These effects were mediated by reticulospinal neurones (RSN) in the nucleus reticluaris pontis caudalis (NRPC) and the nucleus reticularis gigantocellularis (NRG). The majority of RSNs in NRPC received larger inputs from the tectum than from the pyramid, and descended in the ipsilateral ventral funiculus in the C3 segment. RSNs in the NRG, in contrast, had a stronger inputs in general from the pyramid than from the tectum, and descended in the ventrolateral or lateral funiculus of the ipsilateral side or in the contralateral funiculi.
Studies of systematic threshold mapping for evoking antidromic spikes of RSNs in C2-C3 segments and intra-axonal staining of their descending axons in C1-C3 segments with horseradish peroxidase(HRP) revealed the following. Among RSNs, those descending to the brachial segments (C6-Th1) but not down to lumbar segments (C-RSNs) issued collaterals to the ventral horn of C1-C3 segments, while RSNs descended to the lumbar segments gave off collaterals rarely in C1-C3 segments. Direct monosynaptic excitatory connexions of C-RSNs in NRPC and NRG with SPL and BCC motoneurones were demonstrated by spike triggered averaging methods. Their connexions were muscle specific.
The origin of corticoreticular projections was examined. Retrogradely labelled neurones were located, following injection of HRP in NRPC, in the prefrontal cortex(PF), areas 6 and medial half of area 4. In contrast, they were distributed in the lateral 2/3 of area 4 and area 6 following injection in the NRG. Intracortical stimulation evoked dominant EPSPs in RSNs in NRPC from area 6 and the medial half of area 4 and small EPSPs from PF, while it evoked large EPSPs in RSNs in NRG from the lateral 2/3 of area 4 and small EPSPs from area 6 but not from PF.

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Sasaki, S.: Neurosci. Res.Suppl. 1. S51 (1985)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki, S.: J. Physiol. Soc. Japan. 47. S-V(1) (1985)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Isa. T.: J. Physiol. Soc. Japan. 48. 247 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Isa, T.: J. Physiol. Soc. Japan. 49. 403 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Isa, T.: Neurosci. Res.,. Suppl. 5. S137 (1987)

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      「研究成果報告書概要(和文)」より
  • [Publications] Hongo, T.: J. Comp. Neurol.262. 159-194 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki,S.: "Muscle specificity of connexion of the reticulospinal neurones in the nucleus reticularis gigantocellularis with dorsal neck motoneurones and spinal accessory nucleus neurones in the cat." Neurosci. Research. Suppl. 1. S51- (1985)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki,S.: "Descending and segmental control of the neck and forelimb movements in the cat." J. Physiol. Soc. Japan. 47. S-V(1) (1985)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Isa,T.: "Input organization of reticulospinal neurones from the cerebral cortex and tectum in the cat." J. Physiol. Soc. Japan. 48. 247- (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Isa,T.: "Effects of lesion of the paramedial ponto-medullary reticular formation on the visually guided orienting movement of the head in cats." J. Physiol. Soc. Japan. 49. 403- (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Isa,T.: "Mono- and disynaptic excitatory projection to dorsal neck motoneurones from the Forel's field H." Neurosci. Research. Suppl. 5. S137- (1987)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1989-03-30  

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