1986 Fiscal Year Final Research Report Summary
Analysis of mechanism of neonatal imprinting of drug-metabolizing enzymes of rat liver
| Project/Area Number |
60480130
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | School of Medicine, Keio University |
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Principal Investigator |
YAMAZOE Yasushi Associate prof., School of Medicine, Keio University, 医学部, 助手 (00112699)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Ryuichi Professor, School of Medicine, Keio University, 医学部, 教授 (40112685)
KAWANO Sumie Assistant prof., School of Medicine, Keio University, 医学部, 助手 (20175293)
NAGATA Kiyoshi Assistant prof., School of Medicine, Keio University, 医学部, 助手 (80189133)
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| Project Period (FY) |
1985 – 1986
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| Keywords | sex-specific cytochrome P-450 / androgen / estrogen / growth hormone / steroid hormone hydroxylases / 薬物代謝酵素 |
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| Research Abstract |
The effects of neonatal imprinting on sex-specific form of cytochrome P-450, P-450-male and P-450-female in rat hepatic microsomes were studied in comparison with the effects on testosterone hydroxylations and drug oxidations. The rats castrated on one day completely lost the expression of P-450-male at 8 weeks of age, but the rats castrated on 5 days had half content of P-450-male of normal adult rats.
However, the administration of testosterone at 8 weeks of age, completely reversed the effect of neonatal castration, in contrast to previous works on testosterone hydroxylations.
The administration of sodium glutamate to neonatal male rats changes the pattern of P-450-male, testosterone hydroxylation and drug oxidation from the male pattern to the female.
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