1987 Fiscal Year Final Research Report Summary
Reduced function of monocytes in patients with autoimmune disease
| Project/Area Number |
60480206
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
内科学一般
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
SUZUKI Hidero University of occupational and Environmental health, 病院長 (60010120)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAKAWA Fumihiko University of occupational and environmental health, 医学部, 助手 (10158967)
OTA Toshiyuki University of occupational and environmental health, 医学部, 講師 (10140930)
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| Project Period (FY) |
1985 – 1987
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| Keywords | Systemic lupus erythematosus (SLE) / Macrophage / Monocyte / HLA-DR / I region associated (Ia) / Accessory function / 補助機能 |
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| Research Abstract |
Recently it has become clear that macrophages, especially Ia-positive cells, play a regulatory role in several immune responses, but only limited data are available in SLE. In order to analyze the mechanism of the abnormal immune functions in SLF, we have studied the function of peripheral blood monocytes as accessory cells for T cell activation. The accessory function of monocytes for conA-induced T cell proliferation was markedly impaired in SLE. The dysfunction of monocytes was markedly demonstrated in active stage of SLE. Furthermore, the percentage of HLA-DR-positive cells in a monocyte population was markedly decreased in active SLE. Namely, the impairment of accessory function of monocytes in SLE seems to be derived from a decrease in HLA-DR-positive monocytes. To date many investigators have reported that antilymphocyte antibodies are present in SLE sera and these antibodies impair several immune functions of lymphocytes. We found antibodies reactive for monocytes in the sera of SLE patients. These antibodies were present in both IgG and IgM fraction, specific for monocytes, and correlated with the activity of disease. Furthermore, the treatment of normal monocytes with these SLE sera and complement resulted in the depletion of their accessory function for T cell activation. These results suggest that the decrease of the HLA-DR-positive monocytes and the accessory function for T cell activation of monocytes are induced by the presence of antibodies reactive for monocytes.
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